[⁶⁸Ga]Ga-PSMA and [⁶⁸Ga]Ga-RM2 PET/MRI vs. Histopathological Images in Prostate Cancer: A New Workflow for Spatial Co-Registration.

ABSTRACT: This study proposed a new workflow for co-registering prostate PET images from a dual-tracer PET/MRI study with histopathological images of resected prostate specimens. The method aims to establish an accurate correspondence between PET/MRI findings and histology, facilitating a deeper understanding of PET tracer distribution and enabling advanced analyses like radiomics. To achieve this, images derived by three patients who underwent both [⁶⁸Ga]Ga-PSMA and [⁶⁸Ga]Ga-RM2 PET/MRI before radical prostatectomy were selected. After surgery, in the resected fresh specimens, fiducial markers visible on both histology and MR images were inserted. An ex vivo MRI of the prostate served as an intermediate step for co-registration between histological specimens and in vivo MRI ex

SUBMITTER: Ghezzo S 

PROVIDER: S-EPMC10451901 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature