Unveiling the Genetic Footprint: Exploring Somatic Mutations in Peripheral Arterial Disease Progression.

ABSTRACT: Peripheral arterial diseases (PADs) are complex cardiovascular conditions influenced by environmental factors and somatic mutations in multiple genes involved in hematopoiesis and inflammation. While traditional risk factors, such as smoking, hypercholesterolemia, and hypertension, have been extensively studied, the role of somatic mutations in PAD progression remains underexplored. The present article intends to provide a comprehensive commentary of the molecular mechanisms, genetic landscape, prognostic significance, and clinical implications of somatic mutations in PADs. The expansion of clonal hematopoiesis of indeterminate potential (CHIP) clones in the circulating blood, named clonal hematopoiesis (CH), leads to the infiltration of these clones into atherosclerotic plaques and the pr

SUBMITTER: Salybekov AA 

PROVIDER: S-EPMC10452092 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature