The Impact of Muscarinic Antagonism on Psychosis-Relevant Behaviors and Striatal [¹¹C] Raclopride Binding in Tau Mouse Models of Alzheimer's Disease.

ABSTRACT: Psychosis that occurs over the course of Alzheimer's disease (AD) is associated with increased caregiver burden and a more rapid cognitive and functional decline. To find new treatment targets, studies modeling psychotic conditions traditionally employ agents known to induce psychosis, utilizing outcomes with cross-species relevance, such as locomotive activity and sensorimotor gating, in rodents. In AD, increased burdens of tau pathology (a diagnostic hallmark of the disease) and treatment with anticholinergic medications have, separately, been reported to increase the risk of psychosis. Recent evidence suggests that muscarinic antagonists may increase extracellular tau. Preclinical studies in AD models have not previously utilized muscarinic cholinergic antagonists as psychotomimetic age

SUBMITTER: Jimenez H 

PROVIDER: S-EPMC10452133 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature