Profile Characterization of Biogenic Amines in Glioblastoma Patients Undergoing Standard-of-Care Treatment.

ABSTRACT:

Introduction

Biogenic amines play important roles throughout cellular metabolism. This study explores a role of biogenic amines in glioblastoma pathogenesis. Here, we characterize the plasma levels of biogenic amines in glioblastoma patients undergoing standard-of-care treatment.

Methods

We examined 138 plasma samples from 36 patients with isocitrate dehydrogenase (IDH) wild-type glioblastoma at multiple stages of treatment. Untargeted gas chromatography-time of flight mass spectrometry (GC-TOF MS) was used to measure metabolite levels. Machine learning approaches were then used to develop a predictive tool based on these datasets.

Results

Surgery was associated with increased levels of 12 metabolites and decreased levels of 11 metabolites. Chemoradiation was associat

SUBMITTER: Aboud O 

PROVIDER: S-EPMC10452138 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature