A Polarity-Sensitive Far-Red Fluorescent Probe for Glucose Sensing through Skin.

ABSTRACT: The field of glucose biosensors for diabetes management has been of great interest over the past 60 years. Continuous glucose monitoring (CGM) is important to continuously track the glucose level to provide better management of the disease. Concanavalin A (ConA) can reversibly bind to glucose and mannose molecules and form a glucose biosensor via competitive binding. Here, we developed a glucose biosensor using ConA and a fluorescent probe, which generated a fluorescent intensity change based on solvatochromism, the reversible change in the emission spectrum dependent on the polarity of the solvent. The direction in which the wavelength shifts as the solvent polarity increases can be defined as positive (red-shift), negative (blue-shift), or a combination of the two, referred to as reverse

SUBMITTER: Colvin L 

PROVIDER: S-EPMC10452146 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature