Genome-Wide Expression Profile in People with Optic Neuritis Associated with Multiple Sclerosis.

ABSTRACT: The aim of this study was to perform a genome-wide expression analysis of whole-blood samples from people with optic neuritis (ON) and to determine differentially expressed mRNAs compared to healthy control subjects. The study included eight people with acute ON and six healthy control subjects. Gene expression was analyzed using DNA microarrays for whole-human-genome analysis, which contain 54,675 25-base pairs. The additional biostatistical analysis included gene ontology analysis and gene set enrichment analysis (GSEA). Quantitative RT-PCR (qPCR) was used to confirm selected differentially expressed genes. In total, 722 differently expressed genes were identified, with 377 exhibiting increased, and 345 decreased, expression. Gene ontology analysis and GSEA revealed that protein phosphor

SUBMITTER: Habek M 

PROVIDER: S-EPMC10452153 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature