A Comprehensive Benchmark of Transcriptomic Biomarkers for Immune Checkpoint Blockades.

ABSTRACT: Immune checkpoint blockades (ICBs) have revolutionized cancer therapy by inducing durable clinical responses, but only a small percentage of patients can benefit from ICB treatments. Many studies have established various biomarkers to predict ICB responses. However, different biomarkers were found with diverse performances in practice, and a timely and unbiased assessment has yet to be conducted due to the complexity of ICB-related studies and trials. In this study, we manually curated 29 published datasets with matched transcriptome and clinical data from more than 1400 patients, and uniformly preprocessed these datasets for further analyses. In addition, we collected 39 sets of transcriptomic biomarkers, and based on the nature of the corresponding computational methods, we categorized t

SUBMITTER: Kang H 

PROVIDER: S-EPMC10452274 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature