Evaluation of Five Mammalian Models for Human Disease Research Using Genomic and Bioinformatic Approaches.

ABSTRACT: The suitability of an animal model for use in studying human diseases relies heavily on the similarities between the two species at the genetic, epigenetic, and metabolic levels. However, there is a lack of consistent data from different animal models at each level to evaluate this suitability. With the availability of genome sequences for many mammalian species, it is now possible to compare animal models based on genomic similarities. Herein, we compare the coding sequences (CDSs) of five mammalian models, including rhesus macaque, marmoset, pig, mouse, and rat models, with human coding sequences. We identified 10,316 conserved CDSs across the five organisms and the human genome based on sequence similarity. Mapping the human-disease-associated single-nucleotide polymorphisms (SNPs) from

SUBMITTER: Jagadesan S 

PROVIDER: S-EPMC10452283 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature