The Role of the Bile Microbiome in Common Bile Duct Stone Development.

ABSTRACT:

Introduction

Common bile duct (CBD) stones are a health concern for 10-20% of individuals with symptomatic gallstones, leading to health complications and placing a burden on healthcare systems. This study was initiated to investigate the changes in microbiome compositions and the metabolic signature associated with CBD stones. The research approach integrated taxonomic and functional data with metabolomics data, complemented by in vivo experiments.

Methods

In a single tertiary healthcare institution, a total of 25 patients were enrolled who had undergone endoscopic retrograde cholangiopancreatography (ERCP) between February 2019 and January 2021. We harvested DNA from bile samples acquired from these individuals. The amplification of the bacterial 16S rRNA gene V3-V4 region

SUBMITTER: Lee J 

PROVIDER: S-EPMC10452286 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature