Assessment of Oxidative Stress-Induced Oral Epithelial Toxicity.

ABSTRACT: Reactive oxygen species (ROS) are highly reactive molecules generated in living organisms and an excessive production of ROS culminates in oxidative stress and cellular damage. Notably, oxidative stress plays a critical role in the pathogenesis of a number of oral mucosal diseases, including oral mucositis, which remains one of cancer treatments' most common side effects. We have shown previously that oral keratinocytes are remarkably sensitive to oxidative stress, and this may hinder the development and reproducibility of epithelial cell-based models of oral disease. Here, we examined the oxidative stress signatures that parallel oral toxicity by reproducing the initial events taking place during cancer treatment-induced oral mucositis. We used three oral epithelial cell lines (an immorta

SUBMITTER: Mohammed AI 

PROVIDER: S-EPMC10452318 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature