Multi-Institutional Evaluation of Pathologists' Assessment Compared to Immunoscore.

ABSTRACT:

Background

The Immunoscore (IS) is a quantitative digital pathology assay that evaluates the immune response in cancer patients. This study reports on the reproducibility of pathologists' visual assessment of CD3+- and CD8+-stained colon tumors, compared to IS quantification.

Methods

An international group of expert pathologists evaluated 540 images from 270 randomly selected colon cancer (CC) cases. Concordance between pathologists' T-score, corresponding hematoxylin-eosin (H&E) slides, and the digital IS was evaluated for two- and three-category IS.

Results

Non-concordant T-scores were reported in more than 92% of cases. Disagreement between semi-quantitative visual assessment of T-score and the reference IS was observed in 91% and 96% of cases before and after trai

SUBMITTER: Willis J 

PROVIDER: S-EPMC10452341 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature