Lipid Metabolism Disorder in Cerebrospinal Fluid Related to Parkinson's Disease.

ABSTRACT:

Background

Abnormal accumulation of lipids is found in dopamine neurons and resident microglia in the substantia nigra of patients with Parkinson's disease (PD). The accumulation of lipids is an important risk factor for PD. Previous studies have mainly focussed on lipid metabolism in peripheral blood, but little attention has been given to cerebrospinal fluid (CSF). We drew the lipidomic signature in CSF from PD patients and evaluated the role of lipids in CSF as biomarkers for PD diagnosis.

Methods

Based on lipidomic approaches, we investigated and compared lipid metabolism in CSF from PD patients and healthy controls without dyslipidaemia in peripheral blood and explored the relationship of lipids between CSF and serum by Pearson correlation analysis.

Results

A tot

SUBMITTER: Qiu J 

PROVIDER: S-EPMC10452343 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature