The Expression Characteristics and Function of the RECQ Family in Pan-Cancer.

ABSTRACT:

Background

The genes of the RECQ DNA helicase family play a part in preserving the stability of the genome and controlling different disease mechanisms. However, the expression features of RECQs in relation to pan-cancer, their correlation with the immune microenvironment of tumors, and the landscape of prognostic power are still undisclosed.

Methods

Various sequence and clinical data extracted from 33 cancers were utilized to generate a comprehensive overview of RECQs in the landscape. Afterward, we discovered variations in gene expression, potential enrichment of functions, genetic alterations, and analysis related to the immune response in tumors. Additionally, we explored the clinical characteristics and diagnostic significance of RECQs. And the important association of

SUBMITTER: Zhou Y 

PROVIDER: S-EPMC10452384 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature