The Mechanisms of Action of Hyperbaric Oxygen in Restoring Host Homeostasis during Sepsis.

ABSTRACT: The perception of sepsis has shifted over time; however, it remains a leading cause of death worldwide. Sepsis is now recognized as an imbalance in host cellular functions triggered by the invading pathogens, both related to immune cells, endothelial function, glucose and oxygen metabolism, tissue repair and restoration. Many of these key mechanisms in sepsis are also targets of hyperbaric oxygen (HBO₂) treatment. HBO₂ treatment has been shown to improve survival in clinical studies on patients with necrotizing soft tissue infections as well as experimental sepsis models. High tissue oxygen tension during HBO₂ treatment may affect oxidative phosphorylation in mitochondria. Oxygen is converted to energy, and, as a natural byproduct, reactive oxygen species a

SUBMITTER: Vinkel J 

PROVIDER: S-EPMC10452474 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature