IGF/mTORC1/S6 Signaling Is Potentiated and Prolonged by Acute Loading of Subtoxicological Manganese Ion.

ABSTRACT: The insulin-like growth factor (IGF)/insulin signaling (IIS) pathway is involved in cellular responses against intracellular divalent manganese ion (Mn²⁺) accumulation. As a pathway where multiple nodes utilize Mn²⁺ as a metallic co-factor, how the IIS signaling patterns are affected by Mn²⁺ overload is unresolved. In our prior studies, acute Mn²⁺ exposure potentiated IIS kinase activity upon physiological-level stimulation, indicated by elevated phosphorylation of protein kinase B (PKB, also known as AKT). AKT phosphorylation is associated with IIS activity; and provides direct signaling transduction input for the mammalian target of rapamycin complex 1 (mTORC1) and its downstream target ribosomal protein S6 (S6). Here, to better define the impa

SUBMITTER: Tang X 

PROVIDER: S-EPMC10452562 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature