Drug-Delivery Silver Nanoparticles: A New Perspective for Phenindione as an Anticoagulant.

ABSTRACT: Anticoagulants prevent the blood from developing the coagulation process, which is the primary cause of death in thromboembolic illnesses. Phenindione (PID) is a well-known anticoagulant that is rarely employed because it totally prevents coagulation, which can be a life-threatening complication. The goal of the current study is to synthesize drug-loaded Ag NPs to slow down the coagulation process. Methods: A rapid synthesis and stabilization of silver nanoparticles as drug-delivery systems for phenindione (PID) were applied for the first time. Results: Several methods are used to determine the size of the resulting Ag NPs. Additionally, the drug-release capabilities of Ag NPs were established. Density functional theory (DFT) calculations were performed for the first time to indicate the n

SUBMITTER: Nikolova S 

PROVIDER: S-EPMC10452578 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature