Combination of Pioglitazone and Metformin Actions on Liver Lipid Metabolism in Obese Mice.

ABSTRACT:

Background

Despite the increasing prevalence rate of nonalcoholic fatty liver disease (NAFLD) worldwide, efficient pharmacotherapeutic regimens against NAFLD still need to be explored. Previous studies found that pioglitazone and metformin therapy could partly ameliorate NAFLD, but their combination therapy effects have not been researched. In the present study, we assessed the protective effects of metformin and pioglitazone combination therapy on liver lipid metabolism in high-fat diet (HFD)-fed mice and investigated the molecular mechanism.

Methods

Male C57BL/6 mice were divided into five groups: normal control; HFD control; metformin monotherapy; pioglitazone monotherapy and combined therapy. After 8 weeks of pharmacological intervention, glucose and lipid metabolism cha

SUBMITTER: Liu J 

PROVIDER: S-EPMC10452643 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature