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Isolation of Fucoxanthin from Sargassum oligocystum Montagne, 1845 Seaweed in Vietnam and Its Neuroprotective Activity.

ABSTRACT: Fucoxanthin extracted and purified from Vietnamese Sargassum oligocystum Montagne, 1845 exhibits various biological activities. In this study, the ability of fucoxanthin to inhibit acetylcholinesterase (AChE), the antioxidant activities, and the expression of antioxidant enzymes were investigated. Fucoxanthin isolated from Vietnamese S. oligocystum showed no cytotoxic effects; moreover, it exhibited AChE inhibitory activity (with an IC₅₀ value of 130.12 ± 6.65 μg mL^-1) and antioxidant activity (with an IC₅₀ value of 3.42 ± 0.15 mg mL^-1). At concentrations of 50 and 100 µg mL^-1, fucoxanthin provided protection against amyloid β-protein fragment 25-35-induced neurotoxicity in a C6 neuronal cell line, and the survival of C6 cells was higher than 81.01% and 80.98%, respectively, compared to the control group (59%). Moreover, antioxidant enzyme activity and quantitative PCR analysis suggested that the neuroprotective effect of fucoxanthin resulted from regulation of the gene expression of antioxidant enzymes (CAT and GPx) and ER pathways (caspase-3 and Bax), as well as the promotion of expression of genes involved in PI3K/Akt signaling (GSK-3β), autophagy (p62 and ATG5), and the biosynthesis of ACh (VAChT and ChAT). Therefore, fucoxanthin extracted from the seaweed S. oligocystum in Vietnam is a potential feedstock source for the production of health foods that exert neuroprotective effects.

SUBMITTER: Hong DD

PROVIDER: S-EPMC10452663 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature

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Isolation of Fucoxanthin from Sargassum oligocystum Montagne, 1845 Seaweed in Vietnam and Its Neuroprotective Activity.

Hong Dang Diem DD Thom Le Thi LT Ha Nguyen Cam NC Thu Ngo Thi Hoai NTH Hien Hoang Thi Minh HTM Tam Luu Thi LT Dat Nguyen Manh NM Duc Tran Mai TM Tru Nguyen Van NV Hang Nguyen Thi Minh NTM Ambati Ranga Rao RR

Biomedicines 20230819 8

Fucoxanthin extracted and purified from Vietnamese Sargassum oligocystum Montagne, 1845 exhibits various biological activities. In this study, the ability of fucoxanthin to inhibit acetylcholinesterase (AChE), the antioxidant activities, and the expression of antioxidant enzymes were investigated. Fucoxanthin isolated from Vietnamese S. oligocystum showed no cytotoxic effects; moreover, it exhibited AChE inhibitory activity (with an IC50 value of 130.12 ± 6.65 μg mL ...[more]

PMID: 37626806

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Isolation of Fucoxanthin from Sargassum oligocystum Montagne, 1845 Seaweed in Vietnam and Its Neuroprotective Activity.

Publications

Isolation of Fucoxanthin from <i>Sargassum oligocystum</i> Montagne, 1845 Seaweed in Vietnam and Its Neuroprotective Activity.

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