Biotransformation of Rutin in In Vitro Porcine Ileal and Colonic Fermentation Models.

ABSTRACT: Quercetin, a polyphenol antioxidant, is widely distributed in food in the form of glycoside rutin, which is not readily absorbed in the gastrointestinal tract. The microbiota of the colon is known to biotransform rutin, generating quercetin aglycones that can be absorbed. We investigated the role of the ileal and colonic microbiota in rutin biotransformation using established in vitro fermentation models. Overall, a higher rate of rutin biotransformation was observed during colonic fermentation compared with ileal fermentation. The colonic microbiome showed higher potential for rutin conversion to quercetin through an increased abundance of α-rhamnosidase- and β-glucosidase-encoding genes compared to the ileal microbiome. Nonetheless, rutin metabolism occurred rapidly during ileal fermenta

SUBMITTER: Ulluwishewa D 

PROVIDER: S-EPMC10452667 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature