Membrane Transporters Involved in Iron Trafficking: Physiological and Pathological Aspects.

ABSTRACT: Iron is an essential transition metal for its involvement in several crucial biological functions, the most notable being oxygen storage and transport. Due to its high reactivity and potential toxicity, intracellular and extracellular iron levels must be tightly regulated. This is achieved through transport systems that mediate cellular uptake and efflux both at the level of the plasma membrane and on the membranes of lysosomes, endosomes and mitochondria. Among these transport systems, the key players are ferroportin, the only known transporter mediating iron efflux from cells; DMT1, ZIP8 and ZIP14, which on the contrary, mediate iron influx into the cytoplasm, acting on the plasma membrane and on the membranes of lysosomes and endosomes; and mitoferrin, involved in iron transport into th

SUBMITTER: Pasquadibisceglie A 

PROVIDER: S-EPMC10452680 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature