Acute Myocardial Infarction and Risk of Cognitive Impairment and Dementia: A Review.

ABSTRACT: Cognitive impairment (CI) shares common cardiovascular risk factors with acute myocardial infarction (AMI), and is increasingly prevalent in our ageing population. Whilst AMI is associated with increased rates of CI, CI remains underreported and infrequently identified in patients with AMI. In this review, we discuss the evidence surrounding AMI and its links to dementia and CI, including pathophysiology, risk factors, management and interventions. Vascular dysregulation plays a major role in CI, with atherosclerosis, platelet activation, microinfarcts and perivascular inflammation resulting in neurovascular unit dysfunction, disordered homeostasis and a dysfunctional neurohormonal response. This subsequently affects perfusion pressure, resulting in enlarged periventricular spaces and hipp

SUBMITTER: Thong EHE 

PROVIDER: S-EPMC10452707 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature