Cyclophilin D in Mitochondrial Dysfunction: A Key Player in Neurodegeneration?

ABSTRACT: Mitochondrial dysfunction plays a pivotal role in numerous complex diseases. Understanding the molecular mechanisms by which the "powerhouse of the cell" turns into the "factory of death" is an exciting yet challenging task that can unveil new therapeutic targets. The mitochondrial matrix protein CyPD is a peptidylprolyl cis-trans isomerase involved in the regulation of the permeability transition pore (mPTP). The mPTP is a multi-conductance channel in the inner mitochondrial membrane whose dysregulated opening can ultimately lead to cell death and whose involvement in pathology has been extensively documented over the past few decades. Moreover, several mPTP-independent CyPD interactions have been identified, indicating that CyPD could be involved in the fine regulation of s

SUBMITTER: Coluccino G 

PROVIDER: S-EPMC10452829 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature