Obesity in Severe COVID-19 Patients Has a Distinct Innate Immune Phenotype.

ABSTRACT: Obesity alters the capacity of effective immune responses in infections. To further address this phenomenon in the context of COVID-19, this study investigated how the immunophenotype of leukocytes was altered in individuals with obesity in severe COVID-19. This cross-sectional study enrolled 27 ICU COVID-19 patients (67% women, 56.33 ± 19.55 years) that were assigned to obese (BMI ≥ 30 kg/m², n = 9) or non-obese (BMI < 30kg/m², n = 18) groups. Monocytes, NK, and both Low-Density (LD) and High-Density (HD) neutrophils were isolated from peripheral blood samples, and surface receptors' frequency and expression patterns were analyzed by flow cytometry. Clinical status and biochemical data were additionally evaluated. The frequency of monocytes was negatively correlated

SUBMITTER: Resende AS 

PROVIDER: S-EPMC10452870 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature