A Breast Cancer Polygenic Risk Score Is Feasible for Risk Stratification in the Norwegian Population.

ABSTRACT:

Background

Statistical associations of numerous single nucleotide polymorphisms with breast cancer (BC) have been identified in genome-wide association studies (GWAS). Recent evidence suggests that a Polygenic Risk Score (PRS) can be a useful risk stratification instrument for a BC screening strategy, and a PRS test has been developed for clinical use. The performance of the PRS is yet unknown in the Norwegian population.

Aim

To evaluate the performance of PRS models for BC in a Norwegian dataset.

Methods

We investigated a sample of 1053 BC cases and 7094 controls from different regions of Norway. PRS values were calculated using four PRS models, and their performance was evaluated by the area under the curve (AUC) and the odds ratio (OR). The effect of the PRS on the

SUBMITTER: Akdeniz BC 

PROVIDER: S-EPMC10452897 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature