Imaging Correlates between Headache and Breast Cancer: An [¹⁸F]FDG PET Study.

ABSTRACT: This study aimed to examine brain metabolic patterns on [¹⁸F]Fluorodeoxyglucose ([¹⁸F]FDG) positron emission tomography (PET) in breast cancer (BC), comparing patients with tension-type headache (TTH), migraine (MiG), and those without headache. Further association with BC response to neoadjuvant chemotherapy (NAC) was explored. In this prospective study, BC patients eligible for NAC performed total-body [¹⁸F]FDG PET/CT with a dedicated brain scan. A voxel-wise analysis (two-sample t-test) and a multiple regression model were used to compare brain metabolic patterns among TTH, MiG, and no-headache patients and to correlate them with clinical covariates. A single-subject analysis compared each patient's brain uptake before and after NAC with a healthy

SUBMITTER: Antunovic L 

PROVIDER: S-EPMC10453040 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature