Mediation Analysis of Waist Circumference in the Association of Gut Microbiota with Insulin Resistance in Children.

ABSTRACT:

Background

Persistent gut microbiota (GM) imbalance has been associated with metabolic disease development. This study evaluated the mediating role of waist circumference in the association between GM and insulin resistance (IR) in children.

Methods

This cross-sectional study included 533 children aged between 6 and 12. The anthropometry, metabolic markers, and relative abundance (RA) of five intestinal bacterial species were measured. Path coefficients were estimated using path analysis to assess direct, indirect (mediated by waist circumference), and total effects on the association between GM and IR.

Results

The results indicated a positive association mediated by waist circumference between the medium and high RA of S. aureus with homeostatic model assessme

SUBMITTER: Ayala-Garcia JC 

PROVIDER: S-EPMC10453241 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature