School-Age Outcomes of Antenatal Magnesium Sulphate in Preterm Infants.

ABSTRACT:

Background

Antenatal magnesium sulphate (MgSO₄) therapy given to women at risk of preterm birth reduced the risk of cerebral palsy in early childhood. However, its effect on longer-term neurological outcomes remains uncertain. This study aimed to assess the effects of antenatal MgSO₄ therapy on school-age outcomes of preterm infants.

Methods

We conducted a systematic review and meta-analysis. We searched MEDLINE, EMBASE, CENTRAL, and CINAHL for randomized controlled trials (RCTs). Two reviewers independently evaluated the eligibility for inclusion and extracted data.

Results

Ten RCTs were included. Only two of them were on school-age outcomes. Antenatal MgSO₄ therapy had no impact on cerebral palsy, hearing impairment, neurosensory dis

SUBMITTER: Kobayashi A 

PROVIDER: S-EPMC10453514 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature