Immunotherapy during the Immediate Perioperative Period: A Promising Approach against Metastatic Disease.

ABSTRACT: Tumor excision is a necessary life-saving procedure in most solid cancers. However, surgery and the days before and following it, known as the immediate perioperative period (IPP), entail numerous prometastatic processes, including the suppression of antimetastatic immunity and direct stimulation of minimal residual disease (MRD). Thus, the IPP is pivotal in determining long-term cancer outcomes, presenting a short window of opportunity to circumvent perioperative risk factors by employing several therapeutic approaches, including immunotherapy. Nevertheless, immunotherapy is rarely examined or implemented during this short timeframe, due to both established and hypothetical contraindications to surgery. Herein, we analyze how various aspects of the IPP promote immunosuppression and progre

SUBMITTER: Sandbank E 

PROVIDER: S-EPMC10453707 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature