LRP5, SLC6A3, and SOX10 Expression in Conventional Ameloblastoma.

ABSTRACT: Cell proliferation and invasion are characteristic of many tumors, including ameloblastoma, and are important features to target in possible future therapeutic applications.

Objective

The objective of this study was the identification of key genes and inhibitory drugs related to the cell proliferation and invasion of ameloblastoma using bioinformatic analysis.

Methods

The H10KA_07_38 gene profile database was analyzed by Rstudio and ShinyGO Gene Ontology enrichment. String, Cytoscape-MCODE, and Kaplan-Meier plots were generated, which were subsequently validated by RT-qPCR relative expression and immunoexpression analyses. To propose specific inhibitory drugs, a bioinformatic search using Drug Gene Budger and DrugBank was performed.

Results

A total of 204 significantly

SUBMITTER: Correa-Arzate L 

PROVIDER: S-EPMC10453908 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature