Identification of Intestinal Microbial Community in Gallstone Patients with Metagenomic Next-Generation Sequencing.

ABSTRACT: Gallstone disease (GD) is one of the most common gastrointestinal diseases worldwide. Nowadays, intestinal microbiota are thought to play important roles in the formation of gallstones. In our study, human fecal samples were extracted for metagenomic next-generation sequencing (mNGS) on the Illumina HiSeq platform, followed by bioinformatics analyses. Our results showed that there was a particular intestinal micro-ecosystem in GD patients. In contrast to healthy people, the sequences of Bacteroidetes, Bacteroides and Thetaiotaomicron were obviously more abundant in GD patients at phylum, genus and species levels, respectively. On the other hand, the glycan metabolism and drug resistance, especially for the β-lactams, were the most profound functions of gut microbes in

SUBMITTER: Ding L 

PROVIDER: S-EPMC10453932 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature