Effect of Vitamin D₃ on Chemerin and Adiponectin Levels in Uterus of Polycystic Ovary Syndrome Rats.

ABSTRACT:

Background

Polycystic ovary syndrome (PCOS) is an endocrine disorder with disrupted uterus structure and function. A positive effect of vitamin D₃ (VD₃) in female reproduction was observed. Chemerin (RARRES2) and adiponectin (ADIPOQ) are the main adipokines whose levels are altered in PCOS patients. Therefore, the aim of this study was to investigate the impact of VD₃ supplementation on RARRES2 and ADIPOQ levels in the uterus of PCOS rats.

Methods

We analyzed the plasma levels and uterine transcript and protein expression of RARRES2 and ADIPOQ and their receptors (CCRL2, CMKLR1, GPR1, and ADIPOR1 and ADIPOR2, respectively) in rats with letrozole-induced PCOS.

Results

In control animals, VD₃ did not change plasma levels of bo

SUBMITTER: Pich K 

PROVIDER: S-EPMC10453942 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature