Effect of Dapagliflozin in Patients with Heart Failure: A Systematic Review and Meta-Analysis.

ABSTRACT:

Background

Heart failure (HF) is a major cause of recurrent hospitalization and death worldwide. Sodium-glucose cotransporter-2 inhibitors including dapagliflozin are anti-diabetic drugs with promising cardiovascular (CV) effects. We performed systematic review and meta-analysis of randomized controlled trials investigating the effects of dapagliflozin in heart failure patients.

Methods

We searched PubMed, Scopus and ScienceDirect databases. A total of 1,567 studies from January 2017 to September 10, 2022, were screened. After applying exclusion criteria, 22 studies were retrieved for full-text screening, and nine of them were eligible for this meta-analysis. Effect estimates for dichotomous variables were expressed as risk ratio (RR) and 95% CI. The primary outcomes were th

SUBMITTER: Ali AE 

PROVIDER: S-EPMC10453961 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature