Androgen Deprivation Therapy Unrelated to Alzheimer's Disease in the UK Biobank Cohort.

ABSTRACT:

Background/aim

In a meta-analysis of 14 studies, men who received androgen deprivation therapy (ADT) for prostate cancer had a higher risk of dementia and/or Alzheimer disease (AD) than men who did not receive ADT. The effect was more pronounced when ADT was given for more than 12 months. However, in all these analyses, two of the strongest AD risk factors after age, family history of AD and the apolipoprotein e4 allele, were not included. In the current study, we have used data from the UK Biobank (UKB) that incorporates these two factors.

Patients and methods

Our analysis included all subjects with prostate cancer and AD. Prostate cancer diagnosis was ascertained using the 10th Revision of the International Classification of Diseases (ICD10), C61. AD diagnosis was ascertai

SUBMITTER: Lehrer S 

PROVIDER: S-EPMC10453988 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature