Hydroxyapatite-filled osteoinductive and piezoelectric nanofibers for bone tissue engineering.

ABSTRACT: Osteoporotic-related fractures are among the leading causes of chronic disease morbidity in Europe and in the US. While a significant percentage of fractures can be repaired naturally, in delayed-union and non-union fractures surgical intervention is necessary for proper bone regeneration. Given the current lack of optimized clinical techniques to adequately address this issue, bone tissue engineering (BTE) strategies focusing on the development of scaffolds for temporarily replacing damaged bone and supporting its regeneration process have been gaining interest. The piezoelectric properties of bone, which have an important role in tissue homeostasis and regeneration, have been frequently neglected in the design of BTE scaffolds. Therefore, in this study, we developed novel hydroxyapatite

SUBMITTER: Barbosa F 

PROVIDER: S-EPMC10453998 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature