Practical Use of Immortalized Cells in Medicine: Current Advances and Future Perspectives.

ABSTRACT: In modern science, immortalized cells are not only a convenient tool in fundamental research, but they are also increasingly used in practical medicine. This happens due to their advantages compared to the primary cells, such as the possibility to produce larger amounts of cells and to use them for longer periods of time, the convenience of genetic modification, the absence of donor-to-donor variability when comparing the results of different experiments, etc. On the other hand, immortalization comes with drawbacks: possibilities of malignant transformation and/or major phenotype change due to genetic modification itself or upon long-term cultivation appear. At first glance, such issues are huge hurdles in the way of immortalized cells translation into medicine. However, there are certain

SUBMITTER: Voloshin N 

PROVIDER: S-EPMC10454025 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature