Dynamic Transcriptional Landscape of Mycobacterium smegmatis under Cold Stress.

ABSTRACT: Bacterial adaptation to cold stress requires wide transcriptional reprogramming. However, the knowledge of molecular mechanisms underlying the cold stress response of mycobacteria is limited. We conducted comparative transcriptomic analysis of Mycobacterium smegmatis subjected to cold shock. The growth of M. smegmatis cultivated at 37 °C was arrested just after exposure to cold (acclimation phase) but later (by 24 h) was resumed at a much slower rate (adaptation phase). Transcriptomic analyses revealed distinct gene expression patterns corresponding to the two phases. During the acclimation phase, differential expression was observed for genes associated with cell wall remodeling, starvation response, and osmotic pressure stress, in parallel with global changes in the express

SUBMITTER: Grigorov AS 

PROVIDER: S-EPMC10454040 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature