Adsorption of Ferritin at Nanofaceted Al₂O₃ Surfaces.

ABSTRACT: The influence of nanoscale surface topography on protein adsorption is highly important for numerous applications in medicine and technology. Herein, ferritin adsorption at flat and nanofaceted, single-crystalline Al₂O₃ surfaces is investigated using atomic force microscopy and X-ray photoelectron spectroscopy. The nanofaceted surfaces are generated by the thermal annealing of Al₂O₃ wafers at temperatures above 1000 °C, which leads to the formation of faceted saw-tooth-like surface topographies with periodicities of about 160 nm and amplitudes of about 15 nm. Ferritin adsorption at these nanofaceted surfaces is notably suppressed compared to the flat surface at a concentration of 10 mg/mL, which is attributed to lower adsorption affinities of the

SUBMITTER: Pothineni BK 

PROVIDER: S-EPMC10454126 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature