Dataset Information

Spatial patterns of intrinsic brain activity in rats with capsular stroke.

ABSTRACT:

Background

To explore the neural changes of brain activity in rats with circumscribed capsular infarcts to find a new therapeutic target for promoting the functional recovery.

Methods

A total of 18 capsular infarct rats and 18 normal rats were conducted in this study. All animal use procedures were strictly in accordance with the guide for the care and use of laboratory animals. After establishing the photothrombotic capsular infarct model, the functional magnetic resonance imaging (fMRI) data were collected and analyzed.

Results

The fMRI results indicated that the passive movement would induce strong activation in caudate, putamen, frontal association somatosensory cortex, thalamus dorsolateral, and thalamus midline dorsal in control group, and the passive movement would only induce limited activation mostly in somatosensory cortex, thalamus dorsolateral, and thalamus midline dorsal in capsular infarct models. Capsular infarct makes the cortical activity weaken in sensory-related cortex and subcortical nuclei, including capsular area and thalamus.

Conclusions

Such findings imply that the posterior limb of internal capsule (PLIC) is connected to these structures in function, interacts together with them, and, accordingly, the lesion of PLIC manifests the related symptoms.

SUBMITTER: Ma J

PROVIDER: S-EPMC10454278 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature

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Publications

Spatial patterns of intrinsic brain activity in rats with capsular stroke.

Ma Jie J Li Xue-Jia XJ Liu Wen-Xin WX Teng Fei F Hua Xu-Yun XY

Brain and behavior 20230706 8

<h4>Background</h4>To explore the neural changes of brain activity in rats with circumscribed capsular infarcts to find a new therapeutic target for promoting the functional recovery.<h4>Methods</h4>A total of 18 capsular infarct rats and 18 normal rats were conducted in this study. All animal use procedures were strictly in accordance with the guide for the care and use of laboratory animals. After establishing the photothrombotic capsular infarct model, the functional magnetic resonance imagin ...[more]

PMID: 37415300

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Dataset Information

Spatial patterns of intrinsic brain activity in rats with capsular stroke.

Background

Methods

Results

Conclusions

Publications

Spatial patterns of intrinsic brain activity in rats with capsular stroke.

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