Longitudinal study of gut microbiome in obsessive-compulsive disorder.

ABSTRACT:

Introduction

Patients with obsessive-compulsive disorder (OCD) often have limited exposure to a diverse environment and perform repetitive compulsions such as excessive cleaning and washing, which could lead to altered gut microbiome. Therefore, longitudinal studies that investigate changes in gut microbiome before and after cognitive behavioral therapy based on exposure and response prevention (ERP) are warranted.

Methods

All study participants (N = 64) underwent a structured psychiatric diagnostic interview prior to inclusion. Nutritional intake was assessed with a comprehensive food frequency questionnaire. Stool samples were collected from OCD patients before ERP (n = 32) and 1 month after completion of ERP (n = 15), as well as from healthy controls (HCs; n = 32). Taxono

SUBMITTER: Chen LL 

PROVIDER: S-EPMC10454283 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature