Amyloid-β Tetramers and Divalent Cations at the Membrane/Water Interface: Simple Models Support a Functional Role.

ABSTRACT: Charge polarization at the membrane interface is a fundamental process in biology. Despite the lower concentration compared to the abundant monovalent ions, the relative abundance of divalent cations (Ca²⁺, Mg²⁺, Zn²⁺, Fe²⁺, Cu²⁺) in particular spaces, such as the neuron synapse, raised many questions on the possible effects of free multivalent ions and of the required protection of membranes by the eventual defects caused by the free forms of the cations. In this work, we first applied a recent realistic model of divalent cations to a well-investigated model of a polar lipid bilayer, di-myristoyl phosphatidyl choline (DMPC). The full atomistic model allows a fairly good description of changes in the hydration of charged and polar grou

SUBMITTER: Krupa P 

PROVIDER: S-EPMC10454299 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature