Deciphering the Tumor-Immune-Microbe Interactions in HPV-Negative Head and Neck Cancer.

ABSTRACT: Patients with human papillomavirus-negative head and neck squamous cell carcinoma (HPV-negative HNSCC) have worse outcomes than HPV-positive HNSCC. In our study, we used a published dataset and investigated the microbes enriched in molecularly classified tumor groups. We showed that microbial signatures could distinguish Hypoxia/Immune phenotypes similar to the gene expression signatures. Furthermore, we identified three highly-correlated microbes with immune processes that are crucial for immunotherapy response. The survival of patients in a molecularly heterogenous group shows significant differences based on the co-abundance of the three microbes. Overall, we present evidence that tumor-associated microbiota are critical components of the tumor ecosystem that may impact tumor microenvir

SUBMITTER: Hu M 

PROVIDER: S-EPMC10454300 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature