Implementing Core Genes and an Omnigenic Model for Behaviour Traits Prediction in Genomics.

ABSTRACT: A high number of genome variants are associated with complex traits, mainly due to genome-wide association studies (GWAS). Using polygenic risk scores (PRSs) is a widely accepted method for calculating an individual's complex trait prognosis using such data. Unlike monogenic traits, the practical implementation of complex traits by applying this method still falls behind. Calculating PRSs from all GWAS data has limited practical usability in behaviour traits due to statistical noise and the small effect size from a high number of genome variants involved. From a behaviour traits perspective, complex traits are explored using the concept of core genes from an omnigenic model, aiming to employ a simplified calculation version. Simplification may reduce the accuracy compared to a complete PRS

SUBMITTER: Rancelis T 

PROVIDER: S-EPMC10454355 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature