Platelet-Derived Extracellular Vesicles as Lipid Carriers in Severe Allergic Inflammation.

ABSTRACT: The resolution of inflammation is a complex process that is critical for removing inflammatory cells and restoring tissue function. The dysregulation of these mechanisms leads to chronic inflammatory disorders. Platelets, essential cells for preserving homeostasis, are thought to play a role in inflammation as they are a source of immunomodulatory factors. Our aim was to identify key metabolites carried by platelet-derived extracellular vesicles (PL-EVs) in a model of allergic inflammation. PL-EVs were isolated by serial ultracentrifugation using platelet-rich plasma samples obtained from platelet apheresis from severely (n = 6) and mildly (n = 6) allergic patients and non-allergic individuals used as controls (n = 8). PL-EVs were analysed by a multiplatform approach u

SUBMITTER: Couto-Rodriguez A 

PROVIDER: S-EPMC10454366 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature