Deficiency of Caspase-1 Attenuates HIV-1-Associated Atherogenesis in Mice.

ABSTRACT: Within arterial plaque, HIV infection creates a state of inflammation and immune activation, triggering NLRP3/caspase-1 inflammasome, tissue damage, and monocyte/macrophage infiltration. Previously, we documented that caspase-1 activation in myeloid cells was linked with HIV-associated atherosclerosis in mice and people with HIV. Here, we mechanistically examined the direct effect of caspase-1 on HIV-associated atherosclerosis. Caspase-1-deficient (Casp-1^-/-) mice were crossed with HIV-1 transgenic (Tg26^+/-) mice with an atherogenic ApoE-deficient (ApoE^-/-) background to create global caspase-1-deficient mice (Tg26^+/-/ApoE^-/-/Casp-1^-/-). Caspase-1-sufficient (Tg2

SUBMITTER: Alam MA 

PROVIDER: S-EPMC10454548 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature