The Post-Translational Modifications of Human Salivary Peptides and Proteins Evidenced by Top-Down Platforms.

ABSTRACT: In this review, we extensively describe the main post-translational modifications that give rise to the multiple proteoforms characterized to date in the human salivary proteome and their potential role. Most of the data reported were obtained by our group in over twenty-five years of research carried out on human saliva mainly by applying a top-down strategy. In the beginning, we describe the products generated by proteolytic cleavages, which can occur before and after secretion. In this section, the most relevant families of salivary proteins are also described. Next, we report the current information concerning the human salivary phospho-proteome and the limited news available on sulfo-proteomes. Three sections are dedicated to the description of glycation and enzymatic glycosylation. C

SUBMITTER: Messana I 

PROVIDER: S-EPMC10454625 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature