Impaired Repopulating Ability of Uhrf2^-/- Hematopoietic Progenitor Cells in Mice.

ABSTRACT: UHRF proteins catalyze the ubiquitination of target proteins and are involved in regulating gene expression. Some studies reported a reduced expression of UHRF2 in acute leukemia cells, but the role of UHRF2 in hematopoiesis remains unknown. Here, we generated Uhrf2^-/- mice to clarify the role of UHRF2 deletion in hematopoiesis. Compared to Uhrf2^+/+ mice, Uhrf2^-/- mice showed no differences in complete blood counts, as well as bone marrow (BM) findings and spleen weights. Proportions of cells in progenitor fractions in BM were comparable between Uhrf2^+/+ mice and Uhrf2^-/- mice. However, in competitive repopulation assays with BM transplants (BMT), the proportions of Uhrf2^-/- c

SUBMITTER: Sano T 

PROVIDER: S-EPMC10454722 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature