In Silico Identification of Potential Quadruplex Forming Sequences in LncRNAs of Cervical Cancer.

ABSTRACT: Long non-coding RNAs (lncRNAs) have emerged as auxiliary regulators of gene expression influencing tumor microenvironment, metastasis and radio-resistance in cancer. The presence of lncRNA in extracellular fluids makes them promising diagnostic markers. LncRNAs deploy higher-order structures to facilitate a complex range of functions. Among such structures, G-quadruplexes (G4s) can be detected or targeted by small molecular probes to drive theranostic applications. The in vitro identification of G4 formation in lncRNAs can be a tedious and expensive proposition. Bioinformatics-driven strategies can provide comprehensive and economic alternatives in conjunction with suitable experimental validation. We propose a pipeline to identify G4-forming sequences, protein partners and biological func

SUBMITTER: Singh D 

PROVIDER: S-EPMC10454738 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature