Boldine Alters Serum Lipidomic Signatures after Acute Spinal Cord Transection in Male Mice.

ABSTRACT: Traumatic spinal cord injury (SCI) results in wide-ranging cellular and systemic dysfunction in the acute and chronic time frames after the injury. Chronic SCI has well-described secondary medical consequences while acute SCI has unique metabolic challenges as a result of physical trauma, in-patient recovery and other post-operative outcomes. Here, we used high resolution mass spectrometry approaches to describe the circulating lipidomic and metabolomic signatures using blood serum from mice 7 d after a complete SCI. Additionally, we probed whether the aporphine alkaloid, boldine, was able to prevent SCI-induced changes observed using these 'omics platforms'. We found that SCI resulted in large-scale changes to the circulating lipidome but minimal changes in the metabolome, with boldine ab

SUBMITTER: Graham ZA 

PROVIDER: S-EPMC10454893 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature