Liver dECM-Gelatin Composite Bioink for Precise 3D Printing of Highly Functional Liver Tissues.

ABSTRACT: In recent studies, liver decellularized extracellular matrix (dECM)-based bioinks have gained significant attention for their excellent compatibility with hepatocytes. However, their low printability limits the fabrication of highly functional liver tissue. In this study, a new liver dECM-gelatin composite bioink (dECM gBioink) was developed to overcome this limitation. The dECM gBioink was prepared by incorporating a viscous gelatin mixture into the liver dECM material. The novel dECM gBioink showed 2.44 and 10.71 times higher bioprinting resolution and compressive modulus, respectively, than a traditional dECM bioink. In addition, the new bioink enabled stable stacking with 20 or more layers, whereas a structure printed with the traditional dECM bioink collapsed. Moreover, the proposed d

SUBMITTER: Kim MK 

PROVIDER: S-EPMC10455418 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature