Predicting Dominant Genotypes in Norovirus Seasons in Japan.

ABSTRACT: Human noroviruses are an etiological agent of acute gastroenteritis. Since multiple genotypes co-circulate every season changing their proportions, it may be desirable to develop multivalent vaccines by formulating genotype composition of seed strains to match that of dominant strains. Here, performances of the models for predicting dominant genotypes, defined as the two most prevalent genotypes, were evaluated using observed genotype frequencies in Japan and genomic sequences for GI and GII strains. In the null model, genotype proportions in the target season were predicted to be the same as those in the immediately preceding season. In the fitness model, genotype proportions were predicted taking into account the acquisition of novel P-types through recombination and genotype-specific pr

SUBMITTER: Suzuki Y 

PROVIDER: S-EPMC10455559 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature